Piracetam is the best known nootropic drug.
It's mechanism of action is unknown but most would describe it as facilitating
learning in ways that are hard to quantify. It seems to awaken a noticible
improvement in creativity and lucidity, but it is not a simulant or sedative.
The scientific record on piracetam is quite extensive.It does not seem
to be metabolized by the body, and it's effect is minimal on the dopaminergic
and serotonergic neurotransmitter systems. It does seem to lower acetylcholine
levels slightly.This decline is reversed when choline is given with piracetam.
(Many people report that choline potentiates piracetam.)
Piracetam also seems to have neuroprotective properties, for example,
it seems to block the action of some sedative drugs. This action is fairly
easy to measure and has been studied extensively.Research on piracetam
has been controversial. Piracetam has been found to be particularly useful
in alcohol withdrawal and in treating age-related mental decline and some
forms of drug-resistant depression.It is inexpensive and available over-the-counter
in Mexico.Although it has virtually no toxicity and it's benefits are
well documented, it is not available in the US. Steven Fowlkes has a fairly
good work up on obtaining piracetam and other smart drugs in Mexico on
his excellent
Piracetam has been proven to boost learning and memory in normal subjects
as well as those who suffer cognitive deficits, and is also a cognitive
enhancer under conditions of hypoxia or too little oxygen. Recent expeditions
to climb Mt. Everest have included piracetam as an essential medication
to treat frostbite and memory lapses causes by altitude.
In fact it selectively stimulates the anterior or frontal part of the
forebrain, that part of the brain that has evolved most recently rapidly
and remarkably in the course of our evolution from ape to human and which
is the seat of our higher functions.
It also seems to enhance some forms of protein syntheses in the brain.It's
been proven that protein synthesis is an essential step in laying down
long-term memories.
Perhaps the most intriguing aspect of piracetam is that it has been proven
to increase the flow of information between the right and left hemispheres
of the brain.
As a result of experiments with human subjects one researcher concluded
that piracetam causes the hemispheres to become superconnected.
Since there's increasing evidence that high level brain states are a
product of the integrated and synergistic functioning of both hemispheres
simultaneously we might suspect that piracetam enhances not only simple
learning and memory but creative or syntheses thinking.
Piracetam's capacity to superconnect the hemispheres becomes even more
intriguing in light of the evidence indicating that many of the most widely
used mind machines and techniques for brain enhancement such as binaural
beat frequencies and the sound and light machines function in part by
facilitating integrated hemispheric functioning.
One theory is that since both the machines and piracetam seem to facilitate
interhemispheric communication there might be a potentiating or synergistic
effect when such mind machines are used in combination with piracetam
resulting in a potentiation in brain enhancement effects.
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